Genetic and functional studies of a missense variant in a glutamate transporter, SLC1A3, in Tourette syndrome

ObjectiveAbnormalities in neurotransmission within the cortico-striatal-thalamo-cortical circuitry are implicated in the pathogenesis of Tourette syndrome. Glutamate is a major excitatory neurotransmitter and an important member in the cortico-striatal-thalamo-cortical circuitry. To explore the role