Mechanisms of male infertility in autosomal dominant polycystic kidney disease
2014
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is one of the most prevalent inherited disorders in the world. It’s a systemic disease with preferential renal involvement. However, many other organs can be affected, causing important morbidity. Some cases of male infertility are described in literature. That seems to be related to abnormalities in spermatozoa tail microtubules, atonicity and dilatation of seminal vesicle or distal seminal tract cysts and anomalies associated with chronic renal failure. This article presents a patient who combines the two major mechanisms described in literature for male infertility in ADRKD: immotile spermatozoa and megavesicles. This coincidence supports the idea of a common etiological factor to kidney and infertility anomalies.
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