Investigation on the clinical features and influential factors of adverse transfusion reaction

Objective To investigate and analyze the clinical features of adverse transfusion reactions and the influential factors in our hospital,to improve doctors and nurses' awareness on adverse transfusion reactions that occurred with some patients,and to promote safer blood transfusion practice. Methods Adverse transfusion reaction cases in the First Affiliated Hospital of Sun Yat-sen University from July 2013 to December 2013 were collected. The types,clinical features and influential factors of these cases were analyzed. Results There were 53 cases of adverse transfusion reactions among 10 537 blood transfusion cases. The incidence of adverse transfusion reactions was 0. 503%. The most common type was allergic reaction,accounting for 71. 70%,followed by febrile non-hemolytic transfusion reaction( FNHTR)( at 28. 30%). All patients with adverse transfusion reactions recovered after effective treatment. The incidence of adverse transfusion reaction in Plt was1. 054%,which was higher than other blood products. The incidence of adverse transfusion reaction of patients less than 18 years old and patients in Department of Pediatric Hematology was higher than patients older than 18 years old and the patients in Department of Hematology,respectively. The incidence of adverse transfusion reaction among patients with history of blood transfusion or allergy history was higher than those without( P 0. 05). The incidence of adverse transfusion reaction from RBC transfusion with leukocyte depletion filter was less than those without the filter. Conclusion Transfusion carries risks,thus clinicians must adhere to the indications and avoid unnecessary blood transfusion. Clinicians must also heed caution and apply the leukocyte depletion filter if necessary when patients transfuse Plt,especially for children,patients with history of blood transfusion or allergy and patients in the Department of Pediatric Hematology.