2-Tetradecylglycidic Acid, an Inhibitor of Carnitine Palmitoyltransferase-1, Induces Myocardial Hypertrophy via the AT1 Receptor

Abstract Activation of the antiogensin II, type 1 (AT1) receptor mediates the myocardial response to numerous hypertrophic stimuli. This study tested the hypothesis that 2-tetradecylglycidic acid (TDGA), an oxirane carboxylate inhibitor of mitochondrial carnitine plamitoyltransferase-1, induces myocardial hypertrophy via the AT1 receptor system. Male Sprague–Dawley rats treated with 10 mg TDGA/kg/day for 7 days had a heart wet weight:body weight ratio of 3.58±0.16 mg/g compared with a ratio of 2.79±0.07 for rats treated with vehicle ( P P