Treatment of osteosarcoma of distal femur with mechanical reconstructive limb-salvage surgery using custom-made prosthesis

Objective To evaluate the clinical effects of limb salvage with custom-made prosthesis for the treatment of osteosarcoma of distal femur.Methods Forty-two patients were diagnosed as osteosarcoma of distal femur and received neoadjuvant chemotherapy.At the same time limb-salvage surgery was performed with tumor resection and knee reconstruction using custom-made prosthesis.Results Forty-two cases were followed up for 15 to 55(average 32) months.The rate of short-term complications was 11.9%.According to Enneking function scoring system,it is excellent in 19 cases,good in 21 and fair in 2 cases.32 cases survived without tumor in 2 years and 26 in 5 years.The 5-year survive rate was 61.9%.Conclusion Extensive resection and reconstruction by using custom-made prosthesis with neoadjuvant chemotherapy is effective for osteosarcoma of the distal femur.