Research Progress of Analgesic Effect of Sophora Flavescens Active Ingredients

Pain is a common complex and produce unpleasant mood diseases. Opioid alkaloids are used in clinical surgical trauma and severe pain in advanced cancer treatment,but it can cause a range of adverse drug reactions,including nausea,vomiting,respiratory depression,especially prone to drug dependence,thus limiting the wide application of these drugs. Pharmaceutical preparations of Sophora flavescens are used in anti-tumor therapy,meanwhile can relieve cancerous pain and / or other symptoms,such as herpes zoster neuralgia neuropathic pain. However,analgesic mechanism of Sophora flavescens is not very clear. Some modern pharmacological studies proved that matrine alkaloids from Sophora flavescens,such as matrine,oxymatrine,sophoridine,sophocarpine,oxysophocarpine,have analgesic effects. Now we summarize these five alkaoids to review the analgesic effects of Sophora flavescens.