Efficacy and safety of zenocutuzumab in advanced pancreas cancer and other solid tumors harboring NRG1 fusions.

Alison M. Schram,Eileen M. OReilly,Grainne M. OKane,Koichi Goto,Dong-Wan Kim,Cindy Neuzillet,Patricia Martin-Romano,Michaël Duruisseaux,Misako Nagasaka,Jordi Rodon,Benjamin A. Weinberg,Kumiko Umemoto,Sai-Hong Ignatius Ou,Teresa Macarulla,Christelle De La Fouchardiere,Andrew K. Joe,Ernesto Wasserman,Viktoriya Stalbovskaya,James M. Ford,Alexander Drilon

Efficacy and safety of zenocutuzumab in advanced pancreas cancer and other solid tumors harboring NRG1 fusions.

2021

3003Background: NRG1 fusion proteins are oncogenic drivers in pancreas cancer and other solid tumors. They bind HER3, leading to HER2/HER3 heterodimerization and oncogenic transformation. The activ...

Keywords:

Medicine
Fusion protein
Cancer research
Transformation (genetics)
Pancreas
Cancer

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