Magnetic Resonance Cholangiopancreaticography with Esomeprazole: Comparison between Single and Double Oral Dose

Objectives: The aim of this study was to compare patient's Magnetic Resonance Cholangiopancreaticography (MRCP) control images with the same patient's images after taking 40mg or 80mg Esomeprazole, and to define the medication role in improving visualization quality of images. Patients and Methods: Seventy patients attending gastroenterology clinic at Jordan University Hospital during the period first of January 2007 till the end of December 2007 were in a consecutive manner control images, then either 40 mgs or 80 mgs Esomeprazole was given and images re-obtained compared with control images for each patient. Results: Improvement of Contrast effect on stomach and duodenum in Esomeprazole single dose group was 72.5% and in double dose group was 78.5%, while image effect of pancreatic duct was the same for single dose Esomeprazole and double dose (60%), and their statistical results were in concordance with no considerable difference, and the image effect of the biliary tree didn’t show any significant difference between imaging and statistical results in both groups. Conclusion: Esomeprazole improves images and gives superior quality of Magnetic Resonance Cholangiopancreaticography especially the contrast effect of duodenum and stomach and image effect of pancreaticobiliary ducts. But images obtained from patients given a double dose showed no significant difference to those patients given a single dose except some advantage is seen in favor of double dose group in improving intrahepatic duct images.