The effect of temperature on di(2-ethylhexyl) phthalate leaching from PVC infusion sets exposed to lipid emulsions.
2012
Summary
Poly vinyl chloride (PVC) infusion equipment contains substantial amounts of the plasticiser di(2-ethylhexyl) phthalate (DEHP). We determined the amount of DEHP leached from Mediplus Dual TIVA® Infusion sets, into lipid and non-lipid infusates. Two propofol admixtures (Diprivan® 1%, Propoven® 1%), Intralipid® 10% and 0.9% saline were evaluated as infusates. Solutions were infused through TIVA sets at 12 ml.h−1 for 6 h at 24, 32 and 37 °C. In addition, TIVA sets were filled with 2 ml infusates, sealed and incubated at 24 and 37 °C for 6 h. Di(2-ethylhexyl) phthalate was detected in all lipid infusates after dynamic infusion and static contact, and in 0.9% saline after dynamic infusion at 37 °C. At 32 and 37 °C, the quantity of di(2-ethylhexyl) phthalate leaching into the lipid infusates may exceed the recommended maximum exposure amount set by the European Union for DEHP of 20–48 μg.kg−1.day−1 if lipid based infusates are used for sedation or intravenous feeding of infants or neonates.
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