Evolucija žarišnih epileptiformnih izbijanja u elektroencefalogramu nedonoščadi s oštećenjem bijele tvari
2021
AIM: Advances in neonatal medicine has dramatically improved survival rate of pre-
term infants that are frequently born with numerous neurodevelopmental disabilities including
epileptic seizures and epilepsy. In this dissertation the hypothesis was that localisation of white
matter injury is associated with epileptiform EEG changes and neurodevelopmental outcome.
----- MATERIALS AND METHODS:
In 64 preterm infants we analyzed EEG, brain MRI
and ultrasound and motor d evelopment. We evaluated the relationship of brain white matter
lesion with EEG and lesions of certain brain localisation (segment II crossroads, parietal,
temporal, occipital lobe, basal ganglia, cerebellum and ventriculomegaly) with epileptic seizu-
res and neurodevelopmental outcome.
----- RESULTS:
The total number of white matter lesions was in a positive correlation
with the pathological EEG findings and epileptic seizures in infants. Infants who did not have
visible anterior and posterior crossroads frequen tly had epileptic seizures during newborn
period and worse neurodevelopmental outcome.
----- Conclusion:
The obtained results indicate that white matter damage is associated with
epileptogenesis. Among individual localization, the visibility of segment II as the place where
commissural, projection and associative fibers are crossing has a prognostic value for the
future neurodevelopmental outcome. Further studies are needed in order to determine the
pathogenic factors that contribute to epileptogenesis in infants with white matter lesions.
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