Blood Biomarkers for Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a uniformly fatal neurodegenerative disease for which we currently lack any real effective therapy. The absence of suitable biomarkers is perceived as a significant roadblock to therapy development. As neuron-specific structural components of motor axons, neurofilaments are potential markers of neurodegeneration, particularly phosphorylated neurofilament heavy chain and neurofilament light (NfL) chain in blood and cerebrospinal …