Serum antimüllerian hormone levels are independently related to miscarriage rates after in vitro fertilization–embryo transfer

Objective To investigate whether serum antimullerian hormone (AMH) levels are independently related to miscarriage rates after in vitro fertilization–embryo transfer (IVF-ET). Design Cohort study. Setting University-affiliated IVF-ET center. Patient(s) A total of 1,060 patients who attained a clinical pregnancy after IVF-ET. Interventions(s) Centralized serum AMH measurements were performed within the 12 months before IVF-ET. Binary logistic regression was used to verify whether serum AMH levels were associated with the occurrence of a miscarriage independently from confounding factors, such as age and intensity of ovarian response to controlled ovarian stimulation assessed by the number of oocytes retrieved. Main Outcome Measure(s) Miscarriage rates. Result(s) In patients displaying reduced serum AMH levels, miscarriage rates were significantly increased independently from age and the number of oocytes retrieved. Conclusion(s) The present data indicate that serum AMH levels are independently associated with the occurrence of a miscarriage after IVF-ET.