The gatekeeper mutation T315I confers resistance against small molecules by increasing or restoring the ABL-kinase activity accompanied by aberrant transphosphorylation of endogenous BCR, even in loss-of-function mutants of BCR/ABL.

Afsar Ali Mian,M Schüll,Z Zhao,Claudia Oancea,Alena Hundertmark,Tim Beissert,Oliver G. Ottmann,Martin Ruthardt

The gatekeeper mutation T315I confers resistance against small molecules by increasing or restoring the ABL-kinase activity accompanied by aberrant transphosphorylation of endogenous BCR, even in loss-of-function mutants of BCR/ABL.

2009

Afsar Ali Mian
M Schüll
Z Zhao
Claudia Oancea
Alena Hundertmark
Tim Beissert
Oliver G. Ottmann
Martin Ruthardt

The gatekeeper mutation T315I confers resistance against small molecules by increasing or restoring the ABL-kinase activity accompanied by aberrant transphosphorylation of endogenous BCR, even in loss-of-function mutants of BCR/ABL

Keywords:

Cancer research
Genetics
Philadelphia chromosome
ABL
Endogeny
Point mutation
breakpoint cluster region
Mutant
Mutation
Kinase
Biology
kinase activity

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