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Alena Hundertmark
Alena Hundertmark
Goethe University Frankfurt
ABL
Philadelphia chromosome
breakpoint cluster region
Cancer research
kinase activity
3
Papers
59
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The gatekeeper mutation T315I confers resistance against small molecules by increasing or restoring the ABL-kinase activity accompanied by aberrant transphosphorylation of endogenous BCR, even in loss-of-function mutants of BCR/ABL.
2009
Leukemia
Afsar Ali Mian
M Schüll
Z Zhao
Claudia Oancea
Alena Hundertmark
Tim Beissert
Oliver G. Ottmann
Martin Ruthardt
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Citations (27)
Targeting of the N-terminal coiled coil oligomerization interface by a helix-2 peptide inhibits unmutated and imatinib-resistant BCR/ABL
2008
International Journal of Cancer
Tim Beissert
Alena Hundertmark
Velina Kaburova
Lorena Travaglini
Afsar Ali Mian
Clara Nervi
Martin Ruthardt
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Citations (32)
Targeting the Tetramerization by a Specific Peptide Abrogates the Transformation Potential of BCR/ABL and Some of Its Imatinib-Resistant Mutants.
2006
Blood
Tim Beissert
Alena Hundertmark
Velina Kaburova
Afsar Ali Mian
Lorena Travaglini
Oliver G. Ottmann
Dieter Hoelzer
Clara Nervi
Martin Ruthardt
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