Chronic exposure to electronic cigarette (E-cig) results in impaired cardiovascular function in mice

Electronic cigarettes (E-cigs) are marketed as safe, but there has been insufficient long-term exposure to humans to justify these claims. This is the first study to report the long-term in vivo vascular consequences of 8 mo of exposure (equivalent to ~25 yr of exposure in humans) to E-cig vapor in mice. We report that E-cig exposure increases arterial stiffness and impairs normal vascular reactivity responses, similar to other risk factors, including cigarette smoking, which contribute to the development of cardiovascular disease.