Discovery and SAR of a novel series of 2,4,5,6-tetrahydrocyclopenta[c]pyrazoles as N-type calcium channel inhibitors.

Abstract A novel series of substituted 2,4,5,6-tetrahydrocyclopenta[ c ]pyrazoles were investigated as N-type calcium channel blockers (Ca v 2.2 channels), a chronic pain target. One compound was active in vivo in the rat CFA pain model.