Common variation at 12q24.13 (OAS3) influences chronic lymphocytic leukemia risk

Chronic lymphocytic leukemia (CLL) is the most common form of lymphoid malignancy in Western countries1. Recent multi-stage genome-wide association studies (GWAS) have shown that part of the eight-fold increased risk of CLL seen in first-degree relatives of patients can be ascribed to the co-inheritance of multiple low-risk variants.2, 3, 4, 5, 6