INDOLEAMINE 2,3-DIOXYGENASE (IDO) AND IMMUNE TOLERANCE

The IDO facilitates immune tolerance and is one of the main actors involved in the inhibition of cell proliferation, including activated T cells. IDO induces production of reactive oxygen species (ROS) and nitric oxide (NO) radicals. Several pathways involved in the regulation of immune response are regulated by redox mechanisms. Reactive oxygen and nitrogen species (ROSRNS) and other redox active molecules play key roles in immunity.