Improvement of brain function after surgery in infants with posterior quadrant cortical dysplasia

Abstract Objective To reveal whether neurodevelopmental outcome of infants after epilepsy surgery can be quantitatively assessed by electroencephalography (EEG) functional connectivity analysis. Methods We enrolled 13 infants with posterior quadrant dysplasia aged Results Overall, 77% infants experienced seizure freedom after surgery. The beta- and gamma- range PLI of PSD pairs increased preoperatively. All these pairs normalized postoperatively. Simple linear regression analysis revealed a significant relationship between the postoperative DQ and the postoperative beta-band PLI of ASD pairs. Conclusion Preoperative abnormal hyper-connectivity was normalized to the control level after surgery. The postoperative hyperconnectivity was associated with long-term neurodevelopmental improvement. Significance PLI quantifies neurodevelopmental improvements after posterior quadrantectomy.