Expressions of Wnt3a and Wnt5a in papillary thyroid carcinoma and their clinical significances

Objective To investigate the expressions of Wnt3a and Wnt5a in papillary thyroid carcinoma (PTC) and their clinical significances. Methods Immunohistochemical SABC method was used to detect the expressions of Wnt3a and Wnt5a proteins in PTC tissues and their paracancerous tissues collected from 79 patients in Dandong First Hospital from January 2014 to June 2018, and the relationships between the expressions of Wnt3a and Wnt5a proteins and clinicopathological features of PTC patients were analyzed. The expressions of Wnt3a and Wnt5a proteins in 10 pairs of fresh PTC tissues and paracancerous tissues were detected by Western blot. Results The results of immunohistochemistry showed that the positive expression rates of Wnt3a and Wnt5a proteins in PTC tissues were significantly higher than those in paracancerous tissues [69.6% (55/79) vs. 25.3% (20/79), 60.8% (48/79) vs. 20.2% (16/79)], and the differences were statistically significant (χ 2 values were 31.092 and 26.894, both P 0.05). There was a positive correlation between Wnt3a and Wnt5a proteins expressions in PTC (r= 0.597, P < 0.01). Conclusion The abnormal expressions of Wnt3a and Wnt5a proteins in PTC may be related to the development of PTC. Key words: Thyroid neoplasms; Carcinoma, papillary; Wnt3a; Wnt5a