THE SELECTIVE SEROTONIN REUPTAKE INHIBITORS AND BEHAVIOUR OF ADULT DANIO RERIO IN EXPERIMENTS.

Depression is one the most common form of mental diseases. Due to epidemiological studies, it is common in different age groups including young people. Depression pathogenesis from the point of system perspective view consists of morphofunctional and pathopsychological components. The former can be divided into neuroanatomical, neurophysiological, neurochemical parts. Laboratory animals as experimental models are an invaluable tool for investigating pathogenesis of depressive disorders and creating potential treatments. Aim of study - to elucidate behavioral differences in Danio rerio exposed to selective serotonin reuptake inhibitors (SSRI). In our study Danio rerio was used as an experimental model of depression. In fish forming schools during separation in pairs, anxious and aggressive behavior towards each other was manifested. It contributes to formation of dominant-subordinate relationships. Before administration of fluoxetine and sertraline in all the groups studied, the lower level of fish swimming was observed. They were hyperactive. Aggressive behavior towards each other was not observed. On the third day of the experiment behavior of the fish in groups with fluoxetine and sertraline was different. In group with sertraline 25% of fishes come up to average level. In group with fluoxetine fishes remained at the bottom of the aquarium. On the fifth day of the experiment in the group with sertraline 25% of fishes had an abnormal craniocaudal position of the body in space.