Antioxidant effects of combined vitamins C and E in acute myocardial infarction. The randomized, double-blind, placebo controlled, multicenter pilot Myocardial Infarction and VITamins (MIVIT) trial.
2005
Aims. There is a large body of evidence that reactive oxygen species (ROS) produced during myocardial ischemia and
reperfusion play a crucial role in myocardial damage and endothelial dysfunction. The MIVIT pilot trial was designed to test
the effects of antioxidant vitamins C and E on the clinical outcome of patients with AMI.
Methods and results. In this randomized, double-blind, multicenter trial, 800 patients (mean age 62) with AMI were
randomly allocated to receive, on top of routine medication, one of two treatments: vitamin C (1000 mg/12 h infusion)
followed by 1200 mg/24 h orally and vitamin E (600 mg/24 h) or matching placebo for 30 days.
Primary end point (composite of in-hospital cardiac mortality, non-fatal new myocardial infarction, VT/VF/asystole,
shock/pulmonary edema) occurred less frequently in patients treated with antioxidants (55 [14%] vs 75 [19%], OR 0.82 [95%
CI, 0.68-1.00], p=0.048).
Conclusions. This randomized pilot trial shows that supplementation with antioxidant vitamins is safe and seems to
positively influence the clinical outcome of patients with AMI. A larger study is warranted to provide further evidence of this
promising and inexpensive regimen.
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