In vivo antiarthritic activity of Rosa centifolia L. flower extract.

Introduction: Rosa centifolia L. (Rosaceae) have been used for the treatment of joint pain and rheumatoid arthritis (RA) in the traditional system of medicine. Aim : In this study, the antiarthritic activity of the alcoholic extract from the floral parts of R. centifolia was investigated. Materials and Methods: The anti-inflammatory and antiarthritic activity of R. centifolia alcoholic extract (RCAE: 32, 64, and 128 mg/kg) was evaluated using the carrageenan-induced paw edema and complete Freund's adjuvant (CFA) induced arthritis model. Serum from arthritic rats was collected for the estimation of pro-inflammatory cytokine levels. Further, the safety of RCAE was evaluated in an acute and sub-acute (28-day) oral toxicity study. Results: RCAE (64 and 128 mg/kg) significantly ( P P P Conclusion: The result of study demonstrates the antiarthritic activity of R. centifolia and validates its traditional use for the treatment of RA.