THU0526 Analysis of Bone Mineral Density in Children Aged 0 to 12Y in Guangzhou City

Background In the last years, skeletal health has been a public health issues increasingly concerned by most countries in the world. Skeletal development in childhood makes the basis of bone mineral density (BMD) later in life. The normal growth of bone tissue in childhood influences the obtention of peak bone mass, and may decrease the risk of osteoporosis in adulthood. Thus, in order to prevent or avoid skeletal diseases, It is of great importance to focus on bone health in children and to know more about the influencing factors of BMD. Objectives To explore the children9s bone mineral density (BMD) in Guangzhou City. Methods Quantitative ultrasound was used to check BMD in 2450 children who received physical examination in children health care department of our hospital, SOS value and the corresponding Z-score was recorded. According to Z-score, children were divided into Z-score Results The distribution of children9s BMD SOS value and Z-score accorded with normal distribution. Guangzhou children generally have low BMD and high rate of bone strength insufficiency, especially in infancy, their BMD were mostly at low level, and the smaller the age, the lower BMD Z–score. And in general terms, along with the age increasing,the bone strength Z-score showed a trend of rise. The difference between boys and girls was statistically significant (t =4.314, p=0.000), the girls9 Z-score was significantly lower than boys. About the incidence of bone strength insufficiency, boys group was significantly lower than girls, and the difference was statistically significant (χ 2 =30.746, P=30.746). BMD Z–score was the highest in summer, and the incidence of bone strength insufficiency was lower than other three seasons, the difference was statistically significant (P Conclusions Children in Guangzhou city in China generally have low BMD level and high incidence of bone strength insufficiency, especially in infancy, detection of bone health should be held in all ages, especially from baby. References Cooper C, Westlake S, Harvey N et al. Developmental origins of osteoporotic fracture [J]. Osteoporos Int, 2006, 17(3):337. Liu Li, Zheng zheng. Comparative analysis on the insufficient ratio of children9s bone mineral density of different ages in north China [J]. Maternal and Child Health Care of China, 2013, 28 14):2221-5. Wu Maoping, Sun Jusheng, Gao guixiang et al. Investigation and analysis of associated factors of 780 cases of children9s bone mineral density [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2011, 10(5):452. Wu Tianying, Wang Lizhen, Gu Guixiong et al. Effects of physical activity on bone mineral density in infants [J]. Chinese Journal of Child Health Care, 2008, 16(2):179. Liu Guifang, Xiao JIanguo. Analysis of ultrasonic bone density results of 1525 cases of children [J]. World Health Digest, 2012, 12(49):146-147. Chen Ping. Analysis of ultrasonic bone strength of 1886 cases of children aged 0 to 6 [J]. China Hwalth Care & nutrition, 2013, 07(7):642-643. Disclosure of Interest None declared