Mechanisms of125I-omnipaque interactions with rat mononuclear phagocytes

In the absence of plasma proteins,125I-omnipaque interacts with rat isolated peritoneal macrophages due to binding to the cell surface which does not depend on temperature and duration of incubation. In the presence of serum albumin and γ-globulin the binding increases 10-fold, apparently due to phagocytosis of protein-xenobiotic complexes.