Effect of Therapy of Activating Blood and Dredging Meridians,Promoting Urination and Improving Eyesight on Electroretinogram and Visual Field in Patients with Non-ischemic Retinal Vein Obstruction

Objective:To observe the effect of Sanxue Mingmu Tablets(SMT),with the actions of promoting urination and improving eyesight,on electroretinogram(ERG) and visual field in patients with non-ischemic retinal vein obstruction,and to explore its therapeutic mechanism. Methods:Thirty-four qualified patients were equally randomized into the treatment group(involving 17 eyes) and the control group(involving 18 eyes). The two groups received routine western and Chinese medical treatment. Additionally,the treatment group was given SMT,and the control group received Xueshuangtong Tablets. After one treatment course,ERG and computer-based visual field were measured. Results:After treatment,wave crest time of O4 wavelet of oscillatory potentials(Ops) was not delayed in the treatment group(P 0.05). The amplitude of wave a in ERG was(173±25.9)μV,amplitude of wave b was(349±34.6)μV,amplitude of wavelet O2 in Ops was(112.5±12.5)μV,amplitude of wave ∑O in Ops was(174.1±30.7)μV in the treatment group,and the above indexes were increased obviously as compared those in the control group(P 0.05 or P 0.01). The difference of the increase of visual field was significant in both groups before and after treatment(P 0.01). The visual sensitivity at the central 10° of visual field was well recovered in the treatment group(P 0.01 compared with other regions of the visual field),but the difference of visual sensitivity in various regions of the control group was insignificant(P 0.05). Conclusion:SMT is effective for the treatment of non-ischemic retinal vein obstruction,and its therapeutic mechanisms may be related with the improvement of ERG and visual field.