Presence of MUC1 in the epidermal thickening of psoriatic plaques.
2015
Mucin 1 (MUC1) is a transmembrane
glycoprotein that protects epithelial cells from injury
caused by external stimuli. In addition to this role,
MUC1 is involved in cell-cell adhesion, proliferation,
motility, invasion and survival. In epithelial cells, MUC1
expression is regulated by binding of TNFα to TNFR1
and activation of the NFκB pathway. In human skin,
MUC1 is not expressed in normal epidermis but rather in
pre-malignant and malignant conditions. Nevertheless,
the expression of MUC1 and its implication in psoriasis
vulgaris has not been considered. Here, we show that
MUC1 was present in the epidermis of psoriatic plaques
observed in 11 biopsies from patients diagnosed with
psoriasis vulgaris which were compared with 5 normal
human skin. Interestingly, MUC1 in addition to being
localized at the apical surface of some suprabasal
keratinocytes, was also localized over the entire cell
surface of some of these cells and some basal
keratinocytes. Conversely, no MUC1 immunoreactivity
was detected in the epidermis of normal skin.
Additionally, we demonstrated that activated TNFR1, cSrc,
IKKα/β and p50/p65 were present in the epidermal
thickening. This study demonstrates the presence of
MUC1 in psoriatic plaque and suggests a possible role
for MUC1 during the motility, migration and survival of
human keratinocytes, where activated TNFR1, c-Src and
NFκB seem to be required.
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