OPPOSING EFFECTS OF IL-l AND IL-1 ON MALIGNANCY PATTERNS Tumor cell-associated IL- I potentiates anti-tumor immune responses and tumor regression, whereas IL- 1 potentiates invasiveness

Ron N. Apte1, Tatyana Dvorkin1, Xiaoping Song1, Eyal Fima1, Yakov Krelin1, Alon Yulevitch1, Reuven Gurfinkel1, Ariel Werman1, Rosalyn M. White1, Shmuel Argov2, Yacob Shendler2, Olle Bjorkdahl3, Mikael Dohlsten, Margot Zoller, Shraga Segal1 and Elena Voronov1 Department of Microbiology and Immunology, 1Faculty of Health Sciences and The Cancer Research Center, Ben-Gurion University of the Negev, 2Department of Pathology, Soroka Medical Center, Beer-Sheva, Israel, 3University of Lund Luind, Sweden and the 4German Cancer Center, Heidelberg, Germany