Autosomal dominant familial chronic mucocutaneous candidiasis associated with acne rosacea.

Introduction: Autosomal dominant chronic mucocutaneous candidiasis (CMC) without endo- crinopathy (OMIM 114580) is a well-described entity. The associations recorded with this disorder to date are intercellular adhesion molecule-1 (ICAM-1) deficiency and hyper-immuno- globulin E syndrome. Clinical Picture: We report a new association in a family (mother and non- identical twin sons) where acne rosacea is a prominent feature together with CMC. In addition, antibodies to thyroid microsomal and antiparietal cell were also isolated. The autoantibodies might be associated with a current "latent" endocrinopathy in particular autoimmune thyroidi- tis. Treatment: The patient was treated with intermittent pulses of itraconazole for the candidi- asis and doxycycline initially before being substituted with isotretinoin 6 months later for the rosacea. Outcome: The patient's candidiasis responded well and has been in remission for 3 months while his rosacea continues to improve. Ann Acad Med Singapore 2005;34:571-4