Immunohistochemical Study of the Expression of HLA-DR Antigen and Lymphocyte Infiltration in Human Esophageal Carcinoma

The major histocompatibility complex (MHC) class II antigen HLA-DR is known to be present on many types of immunocompetent cells, involved in a variety of immune functions, and can be found in various kinds of cancer cells of the gastrointestinal tract. It is also reported that HLA-DR is associated with tumor invasion, tumor metastasis, and patient survival [1].