Early endoscopic pancreatic and (or) biliary stents combined with Qingyi granules in treatment of acute biliary pancreatitis

Objective To investigate the early (within 72 hours) application and effect of endoscopic pancreatic and (or) biliary stents combined with Qingyi granules in treatment of acute biliary pancreatitis (ABP) patients. Methods A retrospective analysis was done to the 245 patients admitted for ABP from Jan. 2012 to Jan. 2016 in the First Hospital of Lanzhou University. 133 patients (group A) were treated within 72 hours by endoscopic pancreatic and (or) biliary stents combined with Qingyi granules through feeding tube. 112 patients (group B) were treated by endoscopic pancreatic and (or) biliary stents and feeding tube without Qingyi granules. Then the study was done to compare the difference of recover days of abdominal distension, abdominal pain, normalization time of amylase and WBC, length of stay, decrease level of PCT, and the incidence of ABP complications. Results Group A was superior to group B in terms of the recover days of abdominal distension (3.8±3.2) d vs (5.2±2.4) d, abdominal pain (2.6±2.1) d vs (4.9±2.7) d, normalization time of amylase (2.8±1.6) d vs (4.4±3.7) d, WBC (2.6±1.3) d vs (4.1±2.7) d, length of stay (9.4±2.1) d vs (12.6±3.3) d and postoperative PCT level (2.59±2.33) ng/ml vs (3.98±3.03) ng/ml, and the difference had statistical significance (P<0.05) , while there was no significant difference between the two groups in the incidence of ABP complications. Conclusions For ABP patients, early placement of endoscopic pancreatic and (or) biliary duct stents combined with Qingyi granules through feeding tube can remove the etiology, and block the disease from further progress. Early enteral nutrition can contribute to the recovery of intestinal mucosa and the maintenance of internal environment. Combined with Qingyi granules, it can relief the symptoms, decrease the laboratory index and shorten the hospitalization time. Key words: Pancreatic or (and) biliary stents; Qingyi granules; Acute biliary pancreatitis; Endoscopic retrograde cholangipancreatography