Cellulose acetate nanometer electrospun fiber membrane preparation method for releasing prodrug like Naproxen esters
2016
The invention discloses a cellulose acetate nanometer electrospun fiber membrane preparation method for releasing prodrug like Naproxen esters, and the method comprises the steps of dissolving a cellulose acetate in an organic solvent; making the cellulose acetate dissolved fully by ultrasonic vibration; then adding naproxen prodrug and a surfactant respectively in a dissolved solution and making the two dissolved fully and uniformly by ultrasonic vibration to obtain a spinning liquid. The method is simple and safe; the operation is easy; the efficiency is high; a good application prospect in drug loaded nanometer fiber preparation and drug controlled release research is provided; the obtained cellulose acetate nanometer electrospun fiber membrane for releasing prodrug like Naproxen esters can be used to realease a naproxen prodrug slowly, and can be applied in drug release dynamics release characteristic research in medical drug loaded fiber percutaneous release and pertinency treatment to local inflammation and pains.
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