Evaluation of the effectiveness and safety of dexmedetomidine on tracheal intubation in patients with severe craniocerebral injury sedative effect

Objective To investigate the clinical effect and safety of severe craniocerebral injury patients with tracheal intubation of dexmedetomidine sedation. Method 116 patients with severe craniocerebral injury were selected and randomly divided into observation group and control group. Control group (59 cases) to midazolam sedation therapy, observation group (57 cases) received dexmedetomidine sedation therapy. The target sedation time, mechanical ventilation time and the time to wake up and the incidence of adverse reactions were observed and compared between the two groups. Results The target sedation time, mechanical ventilation time and the time to wake up in the observation group were (29.85 ±12.11) min, (135.15±23.67)and(84.16±10.35)min, in the control group were (35.15±10.29)min, (155.26±20.35)h and(105.16±25.17)min. There is a statistically significant difference between groups(t=6.319, 5.869 and 6.124, P<0.05). The incidence of low blood pressure, respiratory depression and delirium were 12.28%, 0 , 5.26% in the observation group and 20.34%, 15.25%, 22.03% in the control group. The differences were statistically significant(χ2=4.327, χ2=7.415 and χ2=6.85, P<0.05). The incidence of of bradycardia were 14.04% in the observation group, and 3.39% in the control group. There was no statistical difference between two groups. Conclusion The application of dexmedetomidine in patients with severe craniocerebral injury of tracheal intubation can obtain satisfactory sedative sedative effect, the incidence rate of adverse reaction is lower, it is a safe and effective sedation scheme. Key words: Severe craniocerebral injury; Dexmedetomidine sedation effect; Trachea cannula; Calm effect