1059 G/C Gene Polymorphism of C-Reactive Protein in Patients with Deep Vein Thrombosis

This study was aimed to investigate the distribution of 1059 G/C gene polymorphism of C-reactive protein(CRP) in deep vein thrombus(DVT) and its clinical significance.Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) was used to screen 1059 G/C polymorphism in exon 2 of C-reactive protein gene in 61 cases of DVT and 60 healthy controls.The frequency of mutation was calculated.The results showed that there was no statistical difference of 1059 G/C genotype and mutation frequency of allele between deep vein thrombosis group and control group(p0.05).It is concluded that the 1059 G/C gene polymorphism of CRP displays certain difference in races and areas,and whether 1059 G/C gene polymorphism of CRP is a dangerous factor for deep vein thrombosis,which needs to be deeply explored.