TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling
2017
Ubiquitination of the GβL subunit, a component of both mTORC1 and mTORC2, acts as a regulatory switching mechanism to balance levels of mTORC1 and mTORC2; the failure of this mechanism in some cancers leads to elevated mTORC2 formation and tumorigenesis.
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