Microscopic resection margin status in pancreatic ductal adenocarcinoma – A nationwide analysis

Abstract Introduction First, this study aimed to assess the prognostic value of different definitions for resection margin status on disease-free survival (DFS) and overall survival (OS) in pancreatic ductal adenocarcinoma (PDAC). Second, preoperative predictors of direct margin involvement were identified. Materials and methods This nationwide observational cohort study included all patients who underwent upfront PDAC resection (2014–2016), as registered in the prospective Dutch Pancreatic Cancer Audit. Patients were subdivided into three groups: R0 (≥1 mm margin clearance), R1 ( Results 595 patients with a median OS of 18 (IQR10-32) months were analysed. R0 (≥1 mm) was achieved in 277 patients (47%), R1 ( Conclusion Resection margin clearance of