Practical Considerations in Management of Non-eosinophilic Asthma

Asthma is heterogeneous disease that can be broadly classified into eosinophilic and non-eosinophilic asthma based on sputum and or blood eosinophils. Noneosinophilic asthma can be further subdivided by predominant inflammatory cell types: neutrophilic, mixed granulocytic, and paucigranulocytic asthma. Patients with non-eosinophilic asthma represent approximately half of all asthma cases in adults and have been shown to have the full spectrum of disease, ranging from mild to severe asthma. Non-eosinophilic asthma accounts for approximately half of all asthma cases, however because its mechanisms are not well understood there are a lack of available therapies targeted to this population. This chapter discusses the major phenotypes of Non-eosinophilic and current treatment approaches.