Clinical study of postoperation analgesia associated buprenorphine with clonidine and bupivacaine

We evaluated the analgesic efficacy, side effects of postoperative epidural analgesic infusions of either buprenorphine plus clonidine, buprenorphine plus bupivacaine or bupivacaine plus 0.9% NaCl after surgery. The forty-five patients undergoing bottom abdominal surgical operation were randomized, double-blind divided into three single epidural infusion groups: A, 0.15 mg buprenorphine added to 0.15 mg clonidine; B,0.15 mg buprenorphine added to 0.2% bupivacaine; C, 0.2% bupivacaine added to 0.9% NaCl. All solutions were diluted with saline to 0.01 L. The efficacy of analgesia, the time for sensory block, the duration of analgesia and hemodynamic effects were monitored during epidural analgesia in each group. The time for sensory block in Group A was the fastest (A:4.13±1.62 min ), the duration of analgesia in group A was the longest (A:1 333.67±209.22 min) and the efficacy of analgesia in group A was the best in the three groups. But a few patients had hemodynamic depression in Group A. A significant improvement in postoperative analgesic efficacy was demonstrated with the epidural administration of the combination of buprenorphine with clonidine in patients after bottom abdominal surgical procedures as compared with other groups. We implicate: The addition of clonidine to buprenorphine significantly increases the analgesia after surgery. The results of this study support the use of epidural analgesic infusions of buprenorphine with clonidine is safe and effective.