pharmaceutical compositions of controlled and prolonged release comprising charged polymers

A bioadhesive pharmaceutical composition of controlled, sustained release agent comprising an ion treatment and an ionic polymer, wherein the composition: (a) is: free (i) of an oil phase; and (ii) hydrated; and (b) includes (i) an ion treatment agent; (Ii) an ionic polymer; and (iii) a complex that includes both an ion treatment agent as an ionic polymer.