Surgical exploration should be tried for patients with primary hyperparathyroidism even the imaging localization is uncertain

Primary hyperparathyroidism (PHPT)with negative or inconsistent imaging is a significant clinical problem. Surgery is the best chance in curing PHPT. Preoperative imaging is performed for lesion localization to help selecting the proper operative approaches. However, negative or inconsistent imaging could not exclude the diagnosis of PHPT and should not be ruled out the decision of operation. Therefore, for PHPT patients who had indication for surgery but with negative or inconsistent imaging result(s), it is better to transfer the patient to experienced center and surgeons for a proper surgical treatment. (Chin J Endocrinol Metab, 2017, 33: 920-922) Key words: Primary hyperparathyroidism; Surgery; Imageological examination