Two Cases of Locally Advanced Rectal Cancer and Lower Rectal Cancer Resected Successfully That Enabled Anus Preservation after Preoperative Chemotherapy

: We reported 2 cases of colorectal cancer receiving neoadjuvant chemotherapy(NAC)with the aim of curative resection or anal preservation. Case 1: A 50-year-old man was diagnosed with locally advanced rectal cancer with sacral invasion. Because of the sacral invasion, we performed preoperative chemotherapy. He was treated with 12 courses of CapeOX plus Bmab and 3 courses of capecitabine plus radiation therapy(45 Gy in total). After chemoradiation therapy, a lower anterior resection was performed. The pathological finding was pT3pN0pM0, pStage Ⅱ. Case 2: A 69-year-old man was diagnosed with lower rectal cancer. Colonoscopy revealed a tumor near the dentate line. Because the patient desired anal preservation, we performed preoperative chemotherapy. He was treated with IRIS plus Bmab. After 3 courses of chemotherapy, the tumor had reduced in size. The pathological findings were no residual tumor cell, pN0. In our hospital, we have preserved the anus in 2 patients after NAC. Including the above 2 cases, we have performed curative resection in 7 cases. The mean observation period after surgery was 30 months; 1 case died from cancer recurrence(41 months after resection)and other 6 cases lived without cancer relapse.