Protect effect of vitamin C on the oxidative injury by PM2.5

Objective To explore the protective effects of vitamin C on the oxidative injury by fine particulate matter 2.5 (PM2.5). Methods Thirty-two healthy adult male wistar rats were selected.We used random number table method and divided patients into four groups(n=8): control group, normal saline group, PM2.5 group, vitamin C group.Pathological morphologic changes were observed under light microscope.MDA、8-OHdG and Hcy in serum were examined. Results Infiltration of inflammatory cells, destroyed alveolars, thickened alveoli septum was noted in PM2.5 group, and we found that the exudation of inflammatory cells in alveolar space and impairment of lung tissue reduced in the vitamin C groups.The levels of MDA、8-OHdG and Hcy in serum increased in PM2.5 group compared with the control group and normal saline group.The levels of MDA, 8-OHdG and Hcy in serum were decreased in vitamin C groups. Conclusions Vitamin C plays an antioxidant role in rat oxidative injury models exposed to PM2.5. Key words: Ascorbic acid; Particulate matter; Oxidative injury