Reproductive performance of pregnant rats and embryotoxic effects of ciprofloxacin.

To observe the effect of ciprofloxacin on both pregnancy and physical development of fetuses, the drug was orally administered to thirty pregnant rats at doses of 20 and 40 mg/kg body weight from day-1 to day-19 of gestation. The intact rat fetuses were isolated on day-19 of gestation. Ciprofloxacin induced general changes in the reproductive performance of female rats and significant alterations in the development of the skeletal parameters of fetuses.