An investigation of the pharmacokinetics and autoinduction of rifabuting metabolism in mice treated with 10 mg/kg/day six times a week for 8 weeks

Plasma, lung and spleen concentrations of rifabutin have been measured in mice after single and multiple oral administrations ofthe drug. Rifabutin concentrations in spleen were similar to those measured in plasma, whereas concentrations in lung were higher. No significant autoinduction of rifabutin metabolism was observed.