A biopsy case of Wilson's disease pathological changes in peripheral nerves

The sural nerve from a patient with'Wilson's hepato-lenticular degeneration was examined by electron microscopy. The myelin sheaths showed remarkable changes and the axons secondary changes, while the unmyelinated nerve fibres were intact. These findings demonstrate that pathological changes of peripheral nerves occur in Wilson's disease. The changes are considered to be primary degeneration of the myelin sheaths.