Solid-phase synthesis of an arylsulfone hydroxamate library

Joseph M. Salvino,Rose Mathew,Terence Kiesow,Ramesh Narensingh,Helen J. Mason,Amy Dodd,Robert D. Groneberg,Christopher J. Burns,Gerald McGeehan,Jane Kline,Edward Orton,Sheng Yuh Tang,Mathew Morrisette,Richard Labaudininiere

Solid-phase synthesis of an arylsulfone hydroxamate library

2000

Joseph M. Salvino
Rose Mathew
Terence Kiesow
Ramesh Narensingh
Helen J. Mason
Amy Dodd
Robert D. Groneberg
Christopher J. Burns
Gerald McGeehan
Jane Kline
Edward Orton
Sheng Yuh Tang
Mathew Morrisette
Richard Labaudininiere

Synthesis of an arylsulfone hydroxamate lead optimization library is presented. Biological activity of representative examples is given to demonstrate the value of this approach for lead optimization.

Keywords:

Enzyme
Chemical synthesis
Organic chemistry
Enzyme inhibitor
Solid-phase synthesis
Biological activity
Biochemistry
Hydroxamic acid
Carboxylic acid
Sulfone
Chemistry
screening test
Phosphoric Diester Hydrolases

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