Clinical aspects of previously treated chromoblastomycosis: a case series from Madagascar.

Abstract Objective To describe the clinical aspects of chromoblastomycosis (CBM) presented by patients who had received incomplete antifungals treatment before the consultation. Methods A prospective study of patients with clinically suspected CBM was performed between 2013 and 2018 at the Department of Dermatology in the University Hospital Antananarivo and during consultation campaigns. Results Patients develop CBM over more than 10 years and many have already received antifungals prescribed by general practitioners before consulting with a dermatologist. Such treatment obviously modifies the clinical presentation. We describe the 12 CBM patients who received oral antifungals (terbinafine, griseofulvine, itraconazole, fluconazole) before the consultation from among the 63 patients of this large study. The most frequent clinical aspect presented by these patients was cicatricial lesions, characterized by relatively smooth, non-elevated lesions that enlarge by peripheral extension, with atrophic scarring at the center. Conclusion Our study is the first to show that cicatricial lesions are a clinical aspect presented by patients who received antifungals before presentation.