Control study of myocardial radionuclide imaging in evaluating the efficacy of bone marrow stem cells transplantation in patients with acute myocardial infarction

Objective: To evaluate the therapeutic efficacy and safety of bone marrow stem cells transplantation in patients with acute myocardial infarction(AMI) using the quantitative analysis of myocardial radionuclide imaging and holter. Methods: Thirty-six patients, who had AMI within 4 weeks, underwent percutaneous coronary intervention(PCI) after AMI with NYHA Ⅱ～Ⅲ class. The patients were divided into trial group[PCI+normal saline(NS)] and control group[PCI+autologous bone marrow mononuclear cells(BM-MNCs)] randomly. NS or BM-MNCs was infused into the infarct related artery through the guiding catheter after PCI in control group and trial group respectively. ECG, holter, SPECT were assessed before PCI, 45d, 90d after that. Result: ①SPECT scan: results showed perfusion defect decreased 34.32% and 23.05% than base-line at 45d in trial and control group respectively, the difference between the two methods was significant(P0.05); and significant difference was also found in both groups. The perfusion decreased 14.77% and 3.82% at 90d compared with 45d in trial and control group respectively(P0.05); but significant difference was not found in both groups, only in trial group. ②24h electrocardiographic monitoring demonstrated that there was no difference in the occurrence of ventriarrhythmia or bradycardia between before PCI, and 45d, 90d after that(P0.05). Conclusions: The quantitative analysis of myocardial radionuclide imaging is a feasible approach to assess the efficacy and safety of bone marrow stem cells transplantation in patients with AMI. And bone marrow stem cells transplantation has some efficacy in patients with AMI and does not increase the incidence of malignant arrhythmias.