[Correlation between JAK2-V617F mutations and variation of peripheral blood cells among BCR/ABL-negative MPD patients].

Objective To assess the correlation between JAK2-V617F mutation and complete blood counts among patients with BCR/ABL-negative myeloproliferative diseases (MPD).Methods One hundred and ninety one patients were recruited.Retrospectively,their laboratory data were analyzed for the counts of red blood cells (RBC),white blood cells (WBC) and platelets (PLT).And the incidence of JAK2-V617F mutation was determined.Results There was significant difference in the incidence of JAK2-V617F mutation between patients with different cell counts (P＜0.01).The incidence of JAK2-V617F mutation has increased with the counts of RBC and PLT,which was the highest (92.86％) among those featuring simultaneous increase in all three series.Conclusion The incidence of JAK2-V617F mutation seems to be strongly associated with variation of peripheral blood cell counts among patients with BCR/ABL-negative MPD.Variation of peripheral blood cells,particularly RBC,may be correlated with the rate of JAK2-V617F mutation. Key words: JAK2-V617F mutation;  Fluorescence quantitative polymerase chain reaction; Myeloproliferative diseases;  BCR/ABL fusion gene