Abstract 10469: Cardiometabolic Risk Factors as Causal Mediators of the Relationship Between High Body Mass Index and Chronic Kidney Disease: A Two-Step Mendelian Randomization Study and Mediation Analyses

Frida Emanuelsson,Kaitlin H Wade,Anette Varbo,Anne Tybjærg-Hansen,George Davey Smith,Børge G. Nordestgaard,Marianne Benn,Nicholas J. Timpson

Abstract 10469: Cardiometabolic Risk Factors as Causal Mediators of the Relationship Between High Body Mass Index and Chronic Kidney Disease: A Two-Step Mendelian Randomization Study and Mediation Analyses

2021

Frida Emanuelsson
Kaitlin H Wade
Anette Varbo
Anne Tybjærg-Hansen
George Davey Smith
Børge G. Nordestgaard
Marianne Benn
Nicholas J. Timpson

Introduction: Observational studies suggest that obesity is a risk factor of chronic kidney disease (CKD). It is unclear whether this reflects a direct causal effect of obesity or an effect mediate...

Keywords:

Obesity
Bioinformatics
two step
Mendelian randomization
Risk factor
Mediation (statistics)
Observational study
Kidney disease
Epidemiology
Medicine

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